THE HER2-DIRECTED ANTIBODY-DRUG CONJUGATE DHES0815A IN ADVANCED AND/OR METASTATIC BREAST CANCER: PRECLINICAL CHARACTERIZATION AND PHASE 1 TRIAL RESULTS

Abstract Approved antibody-drug conjugates (ADCs) for HER2-positive breast cancer include trastuzumab emtansine and trastuzumab deruxtecan.To develop a differentiated HER2 ADC, we chose an antibody that does not compete with trastuzumab or pertuzumab for binding, conjugated to a reduced potency PBD (pyrrolobenzodiazepine) dimer payload.PBDs are pot

The object of the study is Cleaners and Solutions - Instrument High Level Disinfectants the problem of the ongoing epidemic, which affects the entire society and many fields of activity.Using associative logic, I focused on the approach which states that development based on ecology cannot be learned at school as the key of development is awareness

Vaccination against COVID-19 remains one of the ultimate solutions to the ongoing pandemic.This study examined and compared the completion of primary COVID-19 vaccination series and associated factors in the slum and estate communities of Uganda.This was a cross-sectional survey conducted among 1025 slum Paramount Pool Products and estate residents

Knowledge about the pharmacological benefits of different seeds is an important factor for the cultivation and application of medicinal herbs and plants.The seeds of medicinal plants are stores of valuable and active secondary metabolites that have been commercially and economically beneficial and helpful for medicine and pharmacy.The major paramet

The extended pragma-dialectical argumentation theory assumes that people Tampons engaged in argumentative discourse manoeuvre strategically.In argumentative reality, the strategic manoeuvring is often carried out according to an argumentative strategy.Language users make an effort to present their strategic manoeuvres in a specific way and the anal